A Lichen Substance as an Antiproliferative Compound against HL-60 Human Leukemia Cells: 16-O-Acetyl-leucotylic Acid Isolated from Myelochroa aurulenta

Tetsuo TOKIWANO; Hikari SATOH; Tomohisa OBARA; Hiroshi HIROTA; Yuko YOSHIZAWA; Yoshikazu YAMAMOTO

doi:10.1271/bbb.90419

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A Lichen Substance as an Antiproliferative Compound against HL-60 Human Leukemia Cells: 16-O-Acetyl-leucotylic Acid Isolated from Myelochroa aurulenta

Tetsuo TOKIWANO, Hikari SATOH, Tomohisa OBARA, Hiroshi HIROTA, Yuko YOSHIZAWA, Yoshikazu YAMAMOTO

著者情報

キーワード: lichen, triterpene, 16-O-acetyl-leucotylic acid, HL-60, antiproliferation

ジャーナルフリー早期公開

論文ID: 90419

DOI https://doi.org/10.1271/bbb.90419

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 11 p.2525

詳細

抄録

The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC₅₀=21 μM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4).

責任著者(Corresponding author)

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