Two Modes of Autoregulation of the murR Repressor in Escherichia coli

Daiki ISHII; Akira ISHIHAMA; Kaneyoshi YAMAMOTO

doi:10.1271/bbb.90421

This article has now been updated. Please use the final version.

Two Modes of Autoregulation of the murR Repressor in Escherichia coli

Daiki ISHII, Akira ISHIHAMA, Kaneyoshi YAMAMOTO

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Keywords: YfeT, N-acetylymuramic acid, transcription regulation, Escherichia coli

JOURNAL FREE ACCESS Advance online publication

Article ID: 90421

DOI https://doi.org/10.1271/bbb.90421

The final version of this article is now available: Vol. 73 (2009) , No. 11 p.2528

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Abstract

The murPQ operon of Escherichia coli encoding the enzymes for degradation of MurNAc is derepressed by MurR (YfeT) in the presence of MurNAc-6-phosphate. MurR also represses its own expression. We found that murR is stimulated in rich medium. This activation involves MurR and most of the IIBC components of the phosphotransferase system, suggesting auto-induction of murR by an activated form of MurR.

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