Synthesis of Anti-Tumor Dimeric Indole Alkaloids in Catharanthus roseus Was Promoted by Irradiation with Near-Ultraviolet Light at Low Temperature

Mamiko ASANO; Kazuo HARADA; Tomoaki YOSHIKAWA; Takeshi BAMBA; Kazumasa HIRATA

doi:10.1271/bbb.90545

This article has now been updated. Please use the final version.

Synthesis of Anti-Tumor Dimeric Indole Alkaloids in Catharanthus roseus Was Promoted by Irradiation with Near-Ultraviolet Light at Low Temperature

Mamiko ASANO, Kazuo HARADA, Tomoaki YOSHIKAWA, Takeshi BAMBA, Kazumasa HIRATA

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Keywords: FMN, near-ultraviolet light (NUV), Catharanthus roseus, dimeric indole alkaloids (DIAs)

JOURNAL FREE ACCESS Advance online publication

Article ID: 90545

DOI https://doi.org/10.1271/bbb.90545

The final version of this article is now available: Vol. 74 (2010) , No. 2 p.386

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Abstract

We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near-ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near-ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

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