Isolation and Identification of FR198248, a Hydroxylated 1,3-Dihydroisobenzofuran, from Aspergillus flavipes as an Inhibitor of Peptide Deformylase

Yun-Ju KWON; Chang-Ji ZHENG; Won-Gon KIM

doi:10.1271/bbb.90565

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Isolation and Identification of FR198248, a Hydroxylated 1,3-Dihydroisobenzofuran, from Aspergillus flavipes as an Inhibitor of Peptide Deformylase

Yun-Ju KWON, Chang-Ji ZHENG, Won-Gon KIM

著者情報

キーワード: 1,3-dihydroisobenzofuran, peptide deformylase, antibacterial, Staphylococcus aureus, Aspergillus flavipes

ジャーナルフリー早期公開

論文ID: 90565

DOI https://doi.org/10.1271/bbb.90565

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 2 p.390

詳細

抄録

Two highly hydroxylated 1,3-dihydroisobenzofurans, FR198248 (1) and FR202306 (2), were isolated as peptide deformylase (PDF) inhibitors from Aspergillus flavipes. Compounds 1 and 2 inhibited Staphylococus aureus PDF with IC₅₀ values of 3.6 and 2.5 μM, respectively, and also showed antibacterial activity with an MIC value of 25 μg/ml. In contrast, 6-O-methyl derivative 3 of compound 2 was inactive against both PDF and S. aureus.

責任著者(Corresponding author)

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