Hypoglycemic and Hypolipidemic Effects of Hesperidin and Cyclodextrin-Clathrated Hesperetin in Goto-Kakizaki Rats with Type 2 Diabetes

Satoko AKIYAMA; Shin-ichi KATSUMATA; Kazuharu SUZUKI; Yumi NAKAYA; Yoshiko ISHIMI; Mariko UEHARA

doi:10.1271/bbb.90576

This article has now been updated. Please use the final version.

Hypoglycemic and Hypolipidemic Effects of Hesperidin and Cyclodextrin-Clathrated Hesperetin in Goto-Kakizaki Rats with Type 2 Diabetes

Satoko AKIYAMA, Shin-ichi KATSUMATA, Kazuharu SUZUKI, Yumi NAKAYA, Yoshiko ISHIMI, Mariko UEHARA

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Keywords: hesperidin, Goto-Kakizaki rat, type 2 diabetes, glucose-regulating enzyme, lipid

JOURNAL FREE ACCESS Advance online publication

Article ID: 90576

DOI https://doi.org/10.1271/bbb.90576

The final version of this article is now available: Vol. 73 (2009) , No. 12 p.2779

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Abstract

We investigated the hypoglycemic and hypolipidemic effects of two hesperertin glycosides, namely, hesperidin and cyclodextrin (CD)-clathrated hesperetin, in Goto-Kakizaki (GK) weanling rats with type 2 diabetes. We demonstrated that hesperidin and CD-hesperetin normalized glucose metabolism by altering the activities of glucose-regulating enzymes and reducing the levels of lipids in the serum and liver of the GK rats. These effects of hesperidin glycosides were partly produced by altering the expression of genes encoding the peroxisome proliferator-activated receptors, 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, and the low-density lipoprotein receptor.

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