Rapid Regulation of Intestinal Divalent Metal (Cation) Transporter 1 (DMT1/DCT1) and Ferritin mRNA Expression in Response to Excess Iron Loading in Iron-Deficient Rats

Anna ARITA; Kouki TADAI; Shoko SHINODA

doi:10.1271/bbb.90721

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Rapid Regulation of Intestinal Divalent Metal (Cation) Transporter 1 (DMT1/DCT1) and Ferritin mRNA Expression in Response to Excess Iron Loading in Iron-Deficient Rats

Anna ARITA, Kouki TADAI, Shoko SHINODA

著者情報

キーワード: divalent metal transporter 1 (DMT1)/DCT1, ferritin, iron deficiency, excess iron

ジャーナルフリー早期公開

論文ID: 90721

DOI https://doi.org/10.1271/bbb.90721

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 3 p.655

詳細

抄録

We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. DMT1 mRNA was down-regulated and Ft mRNA was up-regulated 2 h after administering the iron. However, more than 2 h was needed for Ft protein synthesis to occur in the duodenal mucosa.

責任著者(Corresponding author)

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