Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
Nana ISOMOTO
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
Yuki FUJITA
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
Hiroyuki FURUTA
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
Yoshiya IKAWA
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University PRESTO, Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency (JST)
Published: April 23, 2010Received: November 17, 2009Available on J-STAGE: -Accepted: January 06, 2010
Advance online publication: April 07, 2010
Revised: -
TransDSL is an RNA ligase ribozyme whose enzyme unit joins two RNA fragments constituting a substrate. The enzyme unit recognizes the substrate by means of two clamp modules. We constructed active variants by replacing the original clamp module with various types of interactions. Such flexible modularity would be advantageous in the application of this ribozyme in nanobiotechnology.
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