In Vitro and in Vivo Evaluation of the Efficacy of Bovine Colostrum against Human Rotavirus Infection

Mizuho INAGAKI; Mayumi YAMAMOTO; XIJIER; CAIRANGZHUOMA; Kenji UCHIDA; Hiroshi YAMAGUCHI; Mihoko KAWASAKI; Kousaku YAMASHITA; Tomio YABE; Yoshihiro KANAMARU

doi:10.1271/bbb.90862

This article has now been updated. Please use the final version.

In Vitro and in Vivo Evaluation of the Efficacy of Bovine Colostrum against Human Rotavirus Infection

Mizuho INAGAKI, Mayumi YAMAMOTO, XIJIER, CAIRANGZHUOMA, Kenji UCHIDA, Hiroshi YAMAGUCHI, Mihoko KAWASAKI, Kousaku YAMASHITA, Tomio YABE, Yoshihiro KANAMARU

Author information

Mizuho INAGAKI
United Graduate School of Agricultural Science, Gifu University
Mayumi YAMAMOTO
Department of Applied Life Science, Gifu University
XIJIER
United Graduate School of Agricultural Science, Gifu University
CAIRANGZHUOMA
Department of Applied Life Science, Gifu University
Kenji UCHIDA
Central R&D Laboratory, Kobayashi Pharmaceutical Co., Ltd.
Hiroshi YAMAGUCHI
Central R&D Laboratory, Kobayashi Pharmaceutical Co., Ltd.
Mihoko KAWASAKI
Central R&D Laboratory, Kobayashi Pharmaceutical Co., Ltd.
Kousaku YAMASHITA
Central R&D Laboratory, Kobayashi Pharmaceutical Co., Ltd.
Tomio YABE
Department of Applied Life Science, Gifu University
Yoshihiro KANAMARU
Department of Applied Life Science, Gifu University

Keywords: bovine colostrum, human rotavirus, infection, diarrhea, suckling mice

JOURNAL FREE ACCESS Advance online publication

Article ID: 90862

DOI https://doi.org/10.1271/bbb.90862

The final version of this article is now available: Vol. 74 (2010) , No. 3 p.680

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Abstract

We found that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal cows at 6–7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro. Furthermore, prophylactic oral administration of SCBLC once before inoculation of HRV prevented the development of diarrhea in suckling mice in vivo. SCBLC from normal cows might be useful in the prevention of HRV-induced severe gastroenteritis in immunocompromised hosts.

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