Studies on Sinomenine

Part LXVIII. (+)-Codeinone from Sinomenine

Abstract

A short survey of sinomenine investigation is given in the theoretical part, prin-cipally on the transformationn of sinomcnine of sinormenine derivatives, hitherto almost unnoticed in morphine derivatives, In experimental, the preparation of (+)-codeinone from sinomenine, reduction of I-bromocodeinone and similar compounds with SnCL₂+HCL₂, and the use of NaBH₄ on the reduction of the ketonic group in sinomenine derivatives are described.