抄録
The changes of metabolisms in the calf, dog and rat following administeration of fluoroacetate were studied. It was found that citrate is accumulated in the tissues, and increased amounts of acetone bodies are excreted in the urine of the animals which received fluoroacetate, and their urinary nitrogen also increases. All these abnormal accumulations and excretions of the rat after injection of fluoroacetate diminish within 24 hrs., suggesting the decrease of the toxity or the excretion of the poison substance.
Significant amounts of organic fluorine compounds were detected in various tissues of fluoroacetate-treated calves.
The lethal dose limit of fluoroacetate for the calf could not be determined. As for the dog, 0.02mg/kilo of fluoroacetate seemed to be fatal.
