Syntheses of Pyrethidic (Chrysanthemumdicarboxylic) Acid

Abstract

Three racemates of pyrethidic (chrysanthemumdicarboxylic) acid were synthesized by various routes including schemes (2), (3), (4) and (5); thus, the total syntheses of three of the possible four racemates were attained. The stereochemical configurations for these racemates were tentatively assigned although no definite evidence was available. d-trans-Pyrethidic acid, naturally occurring chrysanthemumdicarboxylic acid, was also synthesized via scheme (2)