Bulletin of the Agricultural Chemical Society of Japan
Online ISSN : 1881-1272
Print ISSN : 0375-8397
ISSN-L : 0375-8397
Studies on Growth Inhibition of Hiochi-bacteria, Specific Saprophytes of Saké
Part IV. Hydroxyaspergillic Acid as a Growth Inhibitant against Hiochi-bacteria
Seiji NAKAMURATeruo SHIRO
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1959 Volume 23 Issue 5 Pages 418-427

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Abstract
The authors have succeeded in isolating an antibiotic, from the cultured filtrate of Asp. oryzae, responsible for, at least, the majority of the active substances against hiochi-bacteria, as pale yellow crystals of m.p. 152_??_153°C. It has been proved that this antibiotic is identical with hydroxyasper-gillic acid. The minimum concentration for complete inhibition in diluted Saké-peptone medium against true hiochi-bacilli, Lactobacillus homohiochii H-42 and Lactobacillus heterohiochii H-1, was 10 γ/ml, and that against hiochi-lactobacilli H-7 and H-34 20γ/ml.
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