Abstract
The single injection of levulinic acid oxime (250mg/rat) or α-ketoglutaric acid oxime (250mg/rat) on rats, carrying radioactive cesium, promoted both urinary and fecal excretion of this radionuclide. The administration of levulinic acid oxime (sodium salt) decreased the cesium retention by liver. The administration of the oxime did not have influence on the urinary excretion of sodium and potassium in normal rats. The toxicity of the oxime was low. The LD50 of α-ketoglutaric acid oxime was 3500mg/kg (mice, intraperitoneally). (The LD50 of levulinic acid oxime has already been indicated as 2040mg/kg (mice, intravenously)1).
