L-Homoserine Fermentation

Part VI. Effect of Threonine and Methionine on L-Homoserine in Dehydrogenase in Micrococcus glutamicus 534-Co147

Abstract

In the course of studies on “negative feedback control” mechanisms caused by threonineand methionine in L-homoserine fermentation with Micrococcus glutamicus 534-Co147 culture, L-homoserine dehydrogenase was first found to occur in the culture, and effects of variousamino acids on the formation and action of the enzyme were then investigated. The resultwas that L-homoserine dehydrogenase of the culture was repressed by methionine on the onehand, and inhibited by threonine on the other. β-Aspartokinase was found not to be repressedby methionine. From these findings, the sites at which the “negative feedback control” mechanisms work were discussed.