Synthesis of 2-Acetamido-2-deoxy-1, 6-dithio-D-glucose and its Derivatives

抄録

2-Acetamido-3, 4-di-O-acetyl-2, 6-dideoxy-6-S-acetyl-6-thio-D-glucopyranosyl chloride (III) was condensed with potassium thiolacetate, potassium ethylxanthate or thiourea to give three crystalline derivatives of 2-acetamido-2-deoxy-1, 6-dithio-D-glucose. An attempt to prepare 2-acetamido-1, 2, 6-trideoxy-1, 6-dimercapto-D-glucose (VII) from 2-acetamido-3, 4-di-O-acetyl-1, 2, 6-trideoxy-1, 6-di-S-acety1-1, 6-dithio-β-D-glucopyranose was described. 2-Acetamido-3, 4-di-Oacety1-1, 2, 6-trideoxy-1-mercapto-6-S-acetyl-6-thio-β-D-glucopyranose (VIII) was synthesized from the condensation product of III with thiourea.