Abstract
Synthesis of 9-β-D-glucopyranosyl-adenine-6'-phosphate is described. The method developed here involves the process of condensation of base (chloromercuri-6-benzamidopurine)(I) with phosphorylated sugar (2, 3, 4-tri-O-acetyl-6-diphenylphosphoryl-α-D-glucopyranosyl bromide)(II). This reaction gives crystalline 6-benzamido-9-(2', 3', 4'-tri-O-acetyl-6'-diphenylphosphoryl-β-D-glucopyranosyl)-purine (III) in high yield, which is converted to the desired nucleotide by alkaline hydrolysis.
