A New Synthetic Method of Methyl Ketones

Part II. Acidic Cleavage and Ozonolysis Followed by Alkaline Cleavage of Alkyl Mesityl Oxide

Abstract

Alkyl mesityl oxides can be converted to methyl alkyl ketones such as methyl heptanone and hexa-hydropseudoionone by means of the two different methods, i.e., acidic cleavage and ozonolysis followed by alkaline cleavage. Thus, a new synthetic method of methyl ketones (RCH₂COCH₃) from alkyl halides (RX) has been established. The condensation of acetone with alkyl or alkenyl halide in liquid ammonia has been also described.