Synthesis and Properties of Isomeric Di- and Mono- Glucopyranosyl Hypoxanthines

Synthesis in Nucleoside Antibiotics, V

Abstract

Four isomeric glucosyl hypoxanthines, bis-1, 9-(β-D-glucopyranosyl) hypoxanthine (I), bis-1, 7-(β-D-glucopyranosyl) hypoxanthine (II), 7-β-D-glucopyranosyl hypoxanthine (III) and 9-β-D-glucopyranosyl hypoxanthine (IV) were synthesized simultaneously by using the socalled Davoll-Lowy's method. Their synthetic procedures and structural evidences are presented.