1968 Volume 32 Issue 11 Pages 1392-1394
The synthesis of twenty three new N-p-tolyl-N'-2-(substituted)benzothiazolyl-N''-alkyl-guanidines has been reported. Several of these including some N p-tolyl-N'-2-(substitued)-benzothiazolylguanidines* have been evaluated for their antitubercular activity against M. tuberculosis (H 37 Rv) and also for their antibacterial activity. Among these N-p-tolyl-N'-2-(6-methoxy)benzothiazolylguanidine and N p-tolyl-N'-2-(6-methyl)benzothiazolyl-N''-methyl-guanidine are the most active as antituberculars but all the tested compounds are inactive as antibacterials.
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