Agricultural and Biological Chemistry
Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369
Synthesis of Isochroman-1, 3-diones A New Synthesis of (±) Sclerin
Masanao MATSUIYukio SUGIMURAKyohei YAMASHITAKenji MORITomoya OGAWA
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1968 年 32 巻 4 号 p. 492-495

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(±)Sclerin (4, 5, 6, 7-tetramethyl-8-hydroxyisochroman-1, 3-dione), a mycerial extracts of Sclerotinia libertiana, and related compounds were synthesized. Alkylated-7-hydroxyindanones were obtained from alkylated phenols and α-bromobutyrylbromide, and these indanone derivatives were treated with benzaldehyde to give 2-benzylidene-7-hydroxyindanone deri-vatives. By ozonolysis of these benzylidene-indanones were obtained 8-hydroxyisochroman-1, 3-diones.
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© Japan Society for Bioscience, Biotechnology, and Agrochemistry
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