1969 Volume 33 Issue 12 Pages 1730-1736
During the course of our investigations on the metabolism of d-biotin by microorganisms, it has been found that some strains of fungi belonging to the genera Rhodotorula, Penicillium and Endomycopsis, are able to degrade d-biotin oxidatively into various biotin vitamers. The present work was undertaken to characterize these vitamers. The vitamers formed were separated by the ion exchange column chromatography, into Fraction A (d-biotin sulfoxide), Fraction B (unknown vitamer II), Fraction C (d-biotin) and Fraction D (unknown vitamer I). Rf values of vitamer I and vitamer II were found to be different from those of the known biotin vitamers. The vitamers I and II did not support the growth of Lactobacillus arabinosus and Saccharomyces cerevisiae, but did support that of Bacillus subtilis. This degradation reaction occurred rather favorably in high aerobic condition.
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