Studies on α-Alkyl-α-amino Acids

Part I. Synthesis of S-Alkyl-2-methyl-DL-cysteines

Abstract

New eleven S-alkyl-2-methyl-DL-cysteines (V) were synthesized. Alkyl groups are as follows: methyl, ethyl, n-propyl, isopropyl, alkyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-amyl and isoamyl. 5-Alkylthiomethyl-5-methylhydantoins (IV), the synthetic intermediates, which were prepared from alkylthiopropanones (III) by Bucherer's method are also new compounds. Alkyl groups are the same as described above. Chlorine containing two hyd-antoins (IVc, IVd) were also preparared.