Synthesis of Two 3-(7'-Theophyllyl)glycals, 3-Deoxy-3-(7'-theo-phyllyl)-D-xylo-hex-l-enopyranose and Methyl 3-Deoxy-3-(7'-theophyllyl)-D-xylo-hex-l-enopyranuronate, and their Derivatives

Abstract

Two 3-(7'-theophyllyl)glycals, (IV) and (V), were synthesized by fusion of theophylline and the appropriate glycals in the presence of p-toluenesulfonic acid. The structure and stereochemistry of the glycals were determined mainly from NMR analysis of their dihydro and 1, 6-anhydro derivatives.