Syntheses of Paromamine and Its Related Compounds

Abstract

Paromamine and its related compounds were synthesized by a modified Königs-Knorr reaction of 3, 4, 6-tri-O-acetyl-2-(2', 4'-dinitroanilno)-α-D-glucopyranosyl bromide with isopropylidene derivatives of 2-deoxystreptamine, streptamine and dihydroconduramine F-4. The condensed products were isolated as their poly N-acetyl derivatives and proved to have α-configuration by PMR spectroscopy in D₂O.