Fragility of Erythrocytes from Chicks and Rats Fed Dilauryl Succinate and Related Compounds

Abstract

Susceptibility to hydrogen peroxide of the erythrocytes from chicks and rats fed dilauryl succinate and related compounds with and without supplementation of dl-α-tocopheryl acetate was determined.
Dilauryl succinate, lauryl alcohol, n-decyl alcohol, myristyl alcohol, and lauraldehyde were confirmed to make the erythrocytes from the chicks fragile. Supplemented dl-α-tocopheryl acetate of 200mg per kg of diet completely prevented the hemolysis induced by these compounds. Dilauryl succinate also makes the rat's erythrocytes fragile and supplemented dl-α-tocopheryl acetate prevented the hemolysis of the rats, but ethoxyquin was not. The symptoms of encephalomalacia in the chick is preceded by increased hemolysis value of the erythrocytes, and this hemolysis value dropped after the appearance of encephalomalacia.