Production and Isolation of Dopastin, an Inhibitor of Dopamine β-Hydroxylase

Hironobu IINUMA; Shinichi KONDO; Tomio TAKEUCHI; Hamao UMEZAWA

doi:10.1271/bbb1961.38.2093

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Production and Isolation of Dopastin, an Inhibitor of Dopamine β-Hydroxylase

Hironobu IINUMA, Shinichi KONDO, Tomio TAKEUCHI, Hamao UMEZAWA

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JOURNAL FREE ACCESS

1974 Volume 38 Issue 11 Pages 2093-2097

DOI https://doi.org/10.1271/bbb1961.38.2093

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Abstract

A new inhibitor of dopamine β-hydroxylase, dopastin, has been isolated. The dopastinproducing strain was found in a mushroom culture, and after being separated, it was confirmed to be a member of Pseudomonas. Dopastin was obtained as colorless needles, mp 116_??_119°C, [α]²¹_D-246° (c=0.5, C₂H₅OH), C₉H₁₇N₃O₃. The catalytic hydrogenation afforded dihydrodopastin which also inhibits dopamine β-hydroxylase.

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