Abstract
Effect of feeding 4.23, 16.94 and 27.53mg of retinol daily for 10 days on the liver lipids of adult rats has been studied. Feeding of different amounts of retinol produced dose dependent toxicity symptoms in rats. Retinol feeding resulted in significant elevations of liver total lipids, total fatty acids, and glycerides. The amounts of liver esterified cholesterol were significantly raised in rats fed different amounts of retinol. Acetate-1-14C incorporation was increased in liver total cholesterol of rats fed 27.53mg retinol and in free cholesterol of all retinol fed rats. Total 14C activity of hepatic triglycerides of retinol fed rats was the same as that of control, but their specific activity was decreased. Significant alterations were noted in phosphatidyl serine, lysophosphatidyl choline, lysophosphatidyl ethanolamine, sphingomyelin, phosphatidyl choline, phosphatidyl ethanolamine and phosphatidic acid and polyglycerophosphate fractions in liver rats fed different amounts of retinol.
