Isolation and Synthesis of α-Form of Isorhoifolin from Citrus

Abstract

Condensation of 4'-benzylapigenin with α-acetobromorutinose in the presense of silver carbonate or potassium hydroxide followed by deacetylation afforded 4'-benzylapigenin-7-β-rutinoside (VI). Debenzylation of VI resulted in the formation of Isorhoifolin (α-form) (I). I was isolated from the leaves of Tengu orange.