Isolation and Structure of Ascochlorin and Its Analogs
1974 年 38 巻 8 号 p. 1463-1466
詳細
1974 年 38 巻 8 号 p. 1463-1466
Ascochlorin and its analogs were isolated from the filter cake of the fermented broth of a fungus, Ascochyta viciae Libert; the compounds obtained were ascochlorin, LL-Z1272δ, LL-Z1272 ε, ascofuranone, ascofuranol and a new analog, C23H31ClO5. Some of these prenyl phenols show hypolipidemic activity in both normolipidemic and hyperlipidemic rats. Details of the structure determination for ascochlorin are presented. The structure of the new analog was elucidated as 4'-hydroxy-5'-hydroascochlorin.
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