Accumulation of L-Histidinol by a Histidine Auxotroph of Corynebacterium glutamicum and Its Conversion into L-Histidine by an Escherichia coli Strain

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A histidine auxotroph of Corynebacterium glutamicum was found to accumulate L-histidinol in the culture medium. The accumulation of L-histidinol reached a level of 10_??_11 mg as dihydrochloride per ml with a cane molasses medium containing 15% sugar (as glucose), 2_??_3% (NH₄)₂SO₄ and limited amount of L-histidine. When an Escherichia coli strain was mix-cultured with a later phase-culture of the above L-histidinol-producer, 4 mg/ml of L-histidine was produced with the reduction of the L-histidinol accumulation.