Induction and Stabilization of Yeast Aconitase Activity by Fluorocitrate

Abstract

Both fluorocitrate and fluoroacetate acted on yeast aconitase as an inducer and a stabilizer of the enzyme. Fluoroacetate appeared to function after conversion to fluorocitrate in the cells. Inhibitors of protein synthesis and terminal respiratory system showed a strong inhibitory effect on the inductive formation of aconitase. In addition, these fluorocompounds were also found to induce various microbial aconitases.