Degradative Studies on Ezomycins A₁ and A₂

Abstract

On hydrolysis with Dowex 50 W, ezomycin A₁ (1) C₂₆H₄₀N₈O₁₆S gave ezomycin A₂ (2) C₁₉H₂₈N₆O₁₃ and L-cystathionine (3) as main products. Further acid hydrolysis of 2 afforded an amino uronic acid named ezoaminuroic acid (5), 3-amino-3, 4-dideoxy-D-xylohexopyranuroic acid, and cytosine. Ezoaminuroic acid, L-cystathionine and cytosine were found to constitute ezomycin A₁.