Taxonomical Properties of a Producer of Viral-neuraminidase Inhibitor, No. 289 Strain, and Culture Conditions for Inhibitor Production

Abstract

Taxonomical properties of an actinomycete, strain No. 289, a potent producer of viralneuraminidase inhibitor, and culture conditions for the froduction of the inhibitor have been studied. It belongs to the genus Streptomyces and is characterized mainly by spiral formation, smooth spore surface, Gray color-series and chromogenicity. A high yield of the inhibitor was achieved when it was cultured in a medium containing lactose, peptone and yeast extract at 27°C under aerobic condition; the inhibitory activity of the broth reached as high as 2⁴ deHAI units/ml at the fifth day of the main culture.