Abstract
The determination of residues in fresh milk and the metabolic fate of edifenphos (O-ethyl S, S-diphenyl phosphorodithiolate), the active ingredient of the fungicide HINOSAN® were conducted in female goats using gas-liquid chromatographic techniques. Edifenphos was rapidly metabolized to form polar products which were excreted in the urine. The major metabolites found in the urine were O-ethyl S-phenyl hydrogen phosphorothiolate and O-conjugates of m- and p-(hydroxyphenyl) methyl sulfone. Several other metabolites; S, S-diphenyl hydrogen phosphorodithiolate, S-phenyl dihydrogen phosphorothiolate, O-ethyl dihydrogen phosphate, O-ethyl S-phenyl hydrogen phosphorodithiolate and methyl phenyl sulfone were also identified. In the feces, blood, some organs and tissues, edifenphos was scarcely detected. Oral administration of edifenphos to goat at the rate of 10mg/kg resulted the secretion of 0.0008 ppm of edifenphos in milk as the maximum level after 6 hr of the administration.
