Ring Cleavage and Modification at C-2 of a 3, 5'-Cyclonucleoside Derivative of Adenosine

Abstract

It was shown that under alkaline conditions the cyclonucleoside 1 was converted to an imidazole cyclonucleoside 2, and under milder conditions it was converted to an amidine 3, which reacted with N, N'-thiocarbonyldiimidazole and cyanogen bromide as well as phosgene affording the corresponding ring closure products 8, 9 and 10.