Synthesis of Fluoroarylthiazoles and Related Compounds as Possible Fungicides

Abstract

2-Arylamino-4-fluoroarylthiazoles have been synthesized by the condensation of fluoroketones with arylthioureas in presence of iodine. The resulting compounds were mercurated with mercuric acetate. 2-Arylideneamino-4-fluoroarylthiazoles and 2-arylsulfonamido-4-fluoroaryl-5-H/alkyl thiazoles have been synthesised by the condensation of 2-amino-4-fluoro-aryl-5-H/alkylthiazoles with aldehydes and halogenated benzenesulfonyl chlorides respectively. 2-Acetamido-4-fluoroaryl-5-aryloxythiazoles have been synthesized from 2-acetamido-4-fluoroaryl-5-bromothiazoles and sodium salts of phenols. In all sixty two new fluorinated heterocyclic compounds have been prepared. Out of these thirty six were screened against Aspergillus niger and Aspergillus flavus for their antifungal activity. Most of them showed promising results.