Isolation and Characterization of a Novel Antitumor Substance, Renastacarcin

Tetsuo SASAKI; Noboru OTAKE; Akira SHIMAZU; Hiroshi YONEHARA; Akio KOBAYASHI; Hideaki FUKAWA

doi:10.1271/bbb1961.41.1049

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Isolation and Characterization of a Novel Antitumor Substance, Renastacarcin

Tetsuo SASAKI, Noboru OTAKE, Akira SHIMAZU, Hiroshi YONEHARA, Akio KOBAYASHI, Hideaki FUKAWA

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JOURNAL FREE ACCESS

1977 Volume 41 Issue 6 Pages 1049-1054

DOI https://doi.org/10.1271/bbb1961.41.1049

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Abstract

A new antitumor substance designated renastacarcin has been isolated from the cultured broth of Streptomyces violascens by means of DEAE-cellulose and Sephadex G-100 column chromatography. The homogeneity of renastacarcin was confirmed by electrophoreses on a polyacrylamide gel and a cellulose acetate membrane as well as by ultracentrifugal analysis. A sedimentation coefficient at 55, 430 rpm was found to be 2.12 S and the molecular weight was calculated to be 34, 500.

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