Biological Oxidation of Grayanotoxin-II to the 3-Dehydro Derivative by a Microorganism

Abstract

Grayanotoxin (G)-II (1), C₂₀H₃₂O₅, mp 196_??_8°C, is one of the toxic diterpene alcohols obtained from Leucothoe grayana Max (Ericaceae).¹⁾ These alcohols are known for their novel carbon skeleton. We elucidated the biological oxidation of G-II (1) by a microorganism to give 3-dehydro G-II (2), C₂₀H₃₀O₅, mp 233°C.