Reversal of the Antiviral Activity of Tunicamycin by Lipids
1978 年 42 巻 2 号 p. 275-278
詳細
1978 年 42 巻 2 号 p. 275-278
The inhibitory activity of tunicamycin against Newcastle disease virus multiplication was partially reversed by lipids. Phosphatidylcholine, lauric acid and monoglyceride of lauric acid showed the most significant recovering activities among all the tested. But the recovering activity was not observed when tunicamycin was added at a concentration 12-fold greater than the minimal inhibitory concentration. The synergistic effect of phosphatidyl-choline and N-acetyl-D-glucosamine in the recovery indicates different mechanisms of recovery by the two compounds. Recovery of virus multiplication by lipids was suggested to be caused by incorporation of tunicamycin into lipid micelle and decrease of available tunica-mycin in the medium.
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