Nucleotidylation of Aminoglycoside Antibiotics by Bacillus brevis
1979 年 43 巻 12 号 p. 2579-2584
詳細
1979 年 43 巻 12 号 p. 2579-2584
Biochemical transformations of aminoglycoside antibiotics by Bacillus species were exam-ined. Among 39 strains of 8 Bacillus species, 4 strains of B. brevis were found to inactivate several aminoglycoside antibiotics: neamine, xylostasin, butirosin A and kanamycin A.
In the presence of Mg+2 and ATP, the cell-free extracts of B. brevis IFO 12334 catalyzed the transformation of xylostasin to its inactive form. The structure of this inactivated xylo-stasin was determined to be 4'-O-monoadenylylxylostain from the 13C-NMR spectra, and from biochemical and spectroscopic studies.
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