Agricultural and Biological Chemistry
Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369
Serum Lipoproteins in Rats with Amino Acid Imbalance-induced Fatty Liver
Masaji OGURAYoshiko SUEHIRAHideyuki TANAKA
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1979 Volume 43 Issue 2 Pages 331-336

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Abstract
Serum lipoproteins in rats with fatty liver, which was induced by feeding an amino acid imbalanced diet containing 8% casein supplemented with 0.3% of DL-methionine, were analyzed. Three classes of serum lipoproteins, VLDL, LDL and HDL, were isolated by flotation in the ultracentrifuge and their concentration and chemical composition were determined. In serum VLDL of the imbalanced group, the concentration of TG was significantly higher than those for the control group, and that of apoprotein was maintained at the normal level.
These results suggest that this type of fatty liver is not due to a block in the transport of hepatic TG to the plasma. On the contrary, the administration of DL-ethionine resulted in a reduced level of TG of VLDL.
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