Fusariocin C, a New Cytotoxic Substance Produced by Fusarium moniliforme

Abstract

A new cytotoxic substance, fusariocin C, was isolated from the culture filtrate of Fasarium moniliforme A-130. Fusariocin C, C₂₇H₂₈O₈, forms pale yellow prisms, melting at 242_??_244°C and has an optical rotation of [a]²⁰_D-20.6° (c=0.25, CHCl₃). The ultraviolet absorption spectrum was observed at 258 and 365nm.
It was cytotoxic to HeLa cell culture and leukemia L 1210 cells, and showed some anti-tumor activity in vivo for ascitic form of Ehrlich carcinoma. The LD₅₀ by intraperitoneal in-jection in mice was determined to be 3.97mg/kg. This compound was almost devoid of anti-microbial activity.