1979 Volume 43 Issue 6 Pages 1255-1261
Order of the toxicities of the various cobalt complexes to E. coli B were as follows: Cot2+_??_ [Co(C2O4)3]3->[Co(NH3)6]3+>[Co(en)3]3+, [Co(edta)]-, [Co(CN)6]3-=control. The toxici-ties of the complexes are enhanced under a magnesium-free condition. On the other hand, the uptake of cobalt by cells are ordered as follows: [Co(NH3)6]3+>[Co(en)3]3+>Co2+, Co(acac)3, [Co(dip)3]3+>[Co(edta)]-, [Co(C2O4)3]3->[Co(CN)6]3-. In this system, the uptake of Co2+ is energy-linked, and dependent on the magnesium existent, while that of [Co(NH3)6]3+ does not show these characteristics. The strong affinity of [Co(NH3)6]3+ to the membrane was observed.
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