Enhancing Effect of Carbohydrate Pyrolysates on Mutagenesis in Salmonella typhimurium

Abstract

Carbohydrate pyrolysates obtained at 700°C intensively enhanced mutagenicities of several mutagenic agents on Salmonella typhimurium. The pyrolysates obtained by heating from 1 to 15 min had an enhancing effect on the mutagenicity of a similar level. Of the 8 kinds of carbohydrates tested, sucrose pyrolysate showed the highest enhancing effect. The enhancement of mutagenicity by sucrose pyrolysate was much more effective on aromatic amines such as 2-aminofluorene and 2-aminoanthracene than on polycyclic aromatic hydrocarbons. The enhancing effect of sucrose pyrolysate was exhibited in the presence of a metabolic activation system.