Abstract
Effects of temperature, atmosphere and time of heat treatment of albumin on mutagenic activity toward Salmonella typhimurium TA 98, as well as the yield of mutagens, 3-amino-1-methyl-5H-pyrido[4, 3-b]indole and 2-amino-9H-pyrido[2, 3-b]indole were determined in pyrolysis products. Mutagenic activity and mutagen content in the pyrolyzate increased progressively with heating temperature from 200 to 700°C. The effect of heating temperature differed depending on the heating atmosphere, i.e., N2 or air. At 200°C, pyrolyzate mutagenic activity increased with heating time up to 7h, but the mutagenic principles indicated above were not detected.
