抄録
An N-acetylglutamokinase-deficient arginine-requiring mutant, KY9390 and an N-acetylornithine aminotransferase-deficient arginine-requiring mutant, AA-7 were derived from a wild-type strain and an L-arginine-producing mutant of Corynebacterium glutamicum, respectively. KY 9390 accumulated 7.5mg per ml of N-acetylglutamic acid and AA-7 accumulated 2mg per ml of N-acetylglutamate-γ-semialdehyde, intermediates of arginine biosynthesis, in a culture medium.
The production of N-acetylglutamate-β-semialdehyde by AA-7 was not affected by the concentration of L-arginine in the medium, whereas that of N-acetylglutamic acid by KY 9390 was inhibited by the addition of L-arginine in the medium.
