Syntheses and Insecticidal Activity of 8-Isopropyl-6-oxabicyclo[3.2.1]octan-7-one, a Partial Skeleton of Picrotoxinin, and Related Compounds

Abstract

The title lactone trans-7 with a partial structural resembling picrotoxinin 1, which is an antagonist of GABA, and some related lactones were synthesized, and their insecticidal activities were assayed on susceptible and resistant housefly strains. Lactone trans-7 showed the highest activity among the tested compounds in both strains. The configuration of the isopropyl group at C₈ position was important for the insecticidal activity.