Effect of Benzaldehyde on a Malignant Phenotype of Transformed Rat Liver Cells

Abstract

Benzaldehyde (BA) was found to have an inhibitory effect on the proliferation of chemicaltransformed rat liver epithelial cells, Culb TC/R/TC. Such cells treated with BA (2×10^-10_M) ceased proliferation by the 4th or 6th day of cultivation, while control cells continued to proliferate throughout the period (14 days). BA also inhibited the piling-up of cells with no marked morphological change. These effects of BA on cells were seen as temporary and reversible. These data suggested the restoration of the cell-cell contact inhibition to Culb TC/R/TC cells by BAtreatment.