Some Effectors on the Biosynthesis of cis-4-Hydroxy-D-proline in Viridogrisein

Abstract

A system to improve the yield of neoviridogrisein II, in which the cis-4-hydroxy-D-proline is replaced with D-proline, was devised by selective inhibition of the hydroxylation of L-proline with zinc ion in a chemically defined medium. Zinc ion opposed the ferrous ion in the hydroxylation system of Streptomyces griseoviridus P8648.