Isolation and Identification of Aspartate Aminotransferase Inhibitor-producing Microorganism

Abstract

Anactinomycetes producing aspartate aminotransferase inhibitor was isolated from soil.This strain was identified and named Streptomyces sumanensis nov. sp. NK-23 from its taxonomical characteristics. Whenthis strain was aerobically cultured in a mediumcontaining 4% (w/w) glucose, 1.5% meat extract, 1.5% polypeptone and 0.3 % NaCl at pH 7.0, a remarkable amount of the inhibitor (designated as gostatin) was produced in the culture filtrate.